That is why there is a great need to be able to distinguish between the conditions more easily. It is a chronic condition that is believed to be underdiagnosed and as a result is often mistakenly treated with epilepsy medication. Psychogenic seizure is a psychiatric diagnosis that manifests itself through clinical symptoms that can easily be mistaken for epilepsy.
The research team have also compared epileptic seizures with what are known as psychogenic non-epileptic seizures. Her focus is on advanced epilepsy investigations and she has led the research study. She is a group leader and associate professor at Lund University and a Consultant in Clinical Neurophysiology at Skåne University Hospital. We have also taken into account a number of confounding factors that may affect the immune system such as other neurological and immunological illnesses, infections and various psychiatric conditions," says Christine Ekdahl Clementson. "In our study, we have a carefully selected group of participants and we have a lot of background information on each person. Previous studies exist, but the results have so far been mixed and difficult to interpret: That is why researchers started to look for possible biomarkers for epilepsy within the immune system. Inflammation processes that start as an immune response in the body can also provoke a seizure. The condition can be congenital, be caused by a tumor, stroke or infection in the brain and cause very different symptoms depending on which part of the brain the episode begins in or spreads to. Better diagnostic methods as soon as the patient seeks medical care after a suspected seizure are therefore an urgent necessity.Įpilepsy is the collective name for abnormal activity in the brain that causes temporary loss of control of behavior and movement. Diagnosing epilepsy is currently resource intensive, and distinguishing it from other conditions can be challenging. The possible biomarkers can be identified using a simple blood test. Researchers from Lund University in Sweden have discovered higher levels of immune proteins in the blood before and after an epileptic seizure. p-values ≤0.05 were considered statistically significant. Kruskal Wallis H-test was used in A and B and Wilcoxon paired test in C–H. C–H, interictal compared to postictal protein levels of IL-6, MIP1β, TARC, MDC, IFN-y, ICAM-1at 6–8 h and 24 h after temporal lobe seizures. A-B, interictal IL-6 and ICAM-1 protein levels in patients with TLE, FLE, TLE + PNES, PNES, and controls (CTRL). Interictal and postictal immune protein levels in serum from patients with temporal and frontal lobe seizures and PNES.
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